QuickView for matrix metalloproteinase 7;jsessionid=35FD855E404874A0D53FAA04E044034F;jsessionid=32954FF29E089CDD39AB17AB6F722E12 (gene)

Gene Symbol:

MMP7 Homo sapiens

Full name:

matrix metallopeptidase 7

Synonyms:

MMP-7, MPSL1, PUMP-1, matrilysin, matrin, matrix metallopeptidase 7 (matrilysin, uterine), matrix metalloproteinase 7 (matrilysin, uterine), matrix metalloproteinase-7, pump-1 protease, uterine matrilysin, uterine metalloproteinase

Genomic Location:

Chr 11: 101896449-101906688

Description:

This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encode...

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This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGANTCA_AP1_C ,  PEA3_Q6 ,  AP1_Q6 ,  TATAAA_TATA_01 ,  CDX2_Q5 ,  AP1_01 ,  GR_Q6 ,  AP1FJ_Q2 ,  BACH2_01 ,  AP1_Q4 ,  AP1_Q2

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Cytogenetic Map:

11q22.2

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